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Dexamethasone Contraindications

Question#: 701


Does the contraindication of parenteral steroids for dexamethasone include things like depo-provera or testosterone injections?



Testosterone and dexamethasone are two very different types of hormones that have distinct roles and effects in the body.

Depo-provera (medroxyprogesterone acetate) is considered a progestin contraceptive, and while testosterone is a naturally occurring hormone, it is considered androgenic.

Testosterone is a male sex hormone, also present in females in smaller amounts, that is responsible for the development of male sexual characteristics and is involved in the regulation of sexual function, muscle mass, bone density, and the production of red blood cells.

Dexamethasone, on the other hand is a synthetic glucocorticoid hormone. It is a man-made version of the hormone cortisol, which is naturally produced by the adrenal glands in the body. Glucocorticoids like dexamethasone are involved in the regulation of a wide range of physiological processes, including metabolism, immune response, and the body's response to stress. They are also used therapeutically as anti-inflammatory and immunosuppressive agents to treat a variety of conditions.

While testosterone and dexamethasone both play important roles in the body, they have very different mechanisms of action and uses. Testosterone is primarily involved in the regulation of sexual function and muscle development, while dexamethasone is used to treat inflammation and immune-related conditions.

In the context of administering dexamethasone, depo-provera/testosterone are not considered steroids in the same class, and are thus not a contraindication.

Common PO/parenteral steroids (or medications that would be classically considered steroids) given are: Cortisol, prednisone, prednisolone, methylprednisolone, with Dexamethasone being the most common.



18 May 2023



Please reference the MOST RECENT ALS PCS for updates and changes to these directives.